1972: Ph.D. (Biophysics), New York University, New York, NY
1964: B.A. (Biology), New York University, New York, NY
POSITIONS AND HONORS
Positions and Employment
1972-1977: Research Associate, Ophthalmology Mount Sinai School of Medicine
1977-1982: Research Assistant Professor, Ophthalmology, Mount Sinai School of Medicine
1982-1989: Assistant Professor, Ophthalmology Washington University School of Medicine
1989-1994: Associate Professor, Physiology, Medical College of Georgia
1994-1997: Associate Professor, Biological Sciences SUNY College of Optometry
1997-2005: Professor Biological Sciences SUNY College of Optometry
2005-Pres: Distinguished Teaching Professor Biological Sciences SUNY College of Optometry
2003-Pres: Adjunct Professor of Ophthalmology, Columbia University
Other Experience and Professional Membership
1987-Pres: American Physiological Society
1998-Pres: Regular member of Visual Sciences Study Section AED (CSR)
1998-Pres. Adjunct Professor of Physiology (in Ophthalmology), Columbia University
2000- Visiting Professor of Biochemistry, University of Tokyo
1997-Pres: Reviewer of Small Business Grants (MDCN5)
2002–Pres. Visiting Professor of Physiology, Shanghai Second Medical University
2003-Pres. Scientific Advisor, Shanghai Health Science Center
1991- Pres. Consultant for Santen Pharmaceuticals and Wakamoto Pharmaceuticals
2007- Pres. Visiting Professor of Ophthalmology, Xiamen University
Committee Services:
Chairman of Physiology and Pharmacology
Program Planning Committee: Association for Research in Vision and Ophthalmology
Basic Research Science Review Committee
Faculty Tenure and Promotion Committee
Member of AIBS Review Board for evaluation of refractive surgical safety
Regular member Study Section AED CSRA February 2005
Scientific consultant for Wakamoto Pharmaceuticals December 2004
Regular member Visual Sciences Study Section, AED, National Eye Institute, Center
Scientific Review 1997 - 2002
Regular Member of Small Business Review Committee SBRN-4 (NIH)1999 - present
American Institute of Biological Science Special Study Section Member: Refractive Surgery Evaluation for Military 1998 - present
Member of Editorial Board: Proceedings of the Society of Experimental Biology and Medicine 1998 - present
Ad. Hoc. member Visual Sciences Study Section, VISC, National Eye Institute 1996 - 1997
Ad. Hoc. member Visual Sciences Study Section, VISA, National Eye Institute 1996 - 1997 and 2003
Member of Scientific Advisory Board, Santen Pharmaceutical, Osaka, Japan (Scientific Advisor and Manuscript Support for journal submission) 1992-present
Scientific Consultant, Wakamoto Pharmaceutical Co. Tokyo, Japan (Scientific Advisor, support for product presentation to overseas pharmaceutical companies and Manuscript Support for journal submission) 2002-present
Graduate Student Committee
Graduate Student Admissions: Wei Dai (New York Medical College); Sylvia Kang, Fan Zhang, José Capó-Aponte , Zan Pan (SUNY, State College of Optometry)
Doctoral Students: Thesis Committee Member
Wei Dai (New York Medical College); John Sullivan (Mount Sinai School of Medicine)
Masters Students: Thesis Supervisor
Cindy Wang; Fan Zhang; Jojo Du; Wenhong Tao; Weiching Wu; Sylvia Kang; Viviana Tores; José Capó-Aponte;Zan Pan
Laboratory Rotations
Mark Klepner; Don Williams; José Cruz
Professional and Scholarly Associations:
American Physiological Society - Present
Association for Research in Vision and Ophthalmology (ARVO) - Present
Editorial Services (Reviewer):
Current Eye Research
Investigative Ophthalmology and Visual Sciences
American Journal of Physiology
Biochimica et Biophysica Acta
National Science Foundation
Journal of Membrane Biology
Experimental Eye Research
Burroughs Wellcome Trust
Hong Kong Research Foundation
Physiological Genomics
Ophthalmic Research
Experimental Biology and Medicine
Chancellors Award from SUNY for Outstanding Scientific Achievement 2003
Fight for Sight Research Award for Scholarly Excellence 1985
$90,000 (per year)/3 years Academic Investigator Award, National Eye Institute 1977
New York University, Distinguished Ph.D. Dissertation Award 1972
PHARMACEUTICAL COMPANY CONTRACTS:
Resolvyx Pharmaceuticals: Beverly, MA: Roles of Resolvins in Reducing Ocular Inflammation. $50,000 per year
RESEARCH GRANT AND FELLOWSHIPS (PRIMARY INVESTIGATOR):
Monbusho International Research Fellow
Ministry of Education, Japan (1991)
Title: Control of Corneal Epithelial Proliferation
Amount: $300,000 /year
Source:National Eye Institute
Duration: 2003-2008
Status: Active
Title: Control of Corneal Epithelial Proliferation
Amount: $180,000/year
Source:National Eye Institute
Duration:1998 - 2003
Status: Completed
Title: Control of Corneal Epithelial Proliferation
Amount: $125,000/year
Source:National Eye Institute
Duration:1993 - 1998
Status: Completed
Title: Roles of regulatory volume behavior in maintenance of ocular health
Amount: $20,000/year
Source:Georgia Research Supplemental Support
Duration:1992 - 1994
Status:Completed
Title: Second Messenger Roles of cAMP and Ca2+ in Corneal Epithelium
Amount: $142,000/year
Source:National Eye Institute
Duration:1986 - 1991
Status: Completed
Title: Supplement for Impedance Analysis
Amount: $27,500
Source:National Eye Institute
Duration:1984
Status: Completed
Title: Coupling Between Metabolism and Active Ion Transport/Cornea
Amount: $120,000/year
Source:National Eye Institute
Duration:1983 - 1986
Status: Completed
Title: Basic Research Science Grant
Amount: $10,000
Source: Washington University
Duration: 1983
Status: Completed
Title: DC Microelectrode Studies (Supplement)
Amount: $13,211
Source:National Eye Institute
Duration:1982
Status: Completed
Title: Coupling Between Metabolism/Active Ion Transport/Cornea
Amount: $105,000/year
Source:National Eye Institute
Duration: 1980 - 1983
Status: Completed
Title: “Coupling Between Metabolism/Active Ion Transport in Cornea”
Amount:$90,000/year
Source:National Institutes of Health
Duration1977 - 1980
Status: Completed
Title: Effects of Diuretics on Corneal Hydration and Transport
Amount: $75,000/year
Source:National Eye Institute
Duration:1976
Status: Completed
Individual NEI Postdoctoral Fellowship, ($10,000/year) 1973 - 1976
Research Grant Submitted: R21 to NEI (Oct 1, 2005: Signaling mechanisms mediating mouse corneal epithelial healing; 275,000/2 years)
LECTURES AND PRESENTATIONS: (Titles are listed for presentationsin recent years)
- XVII International Congress of Eye Research (ICER), Buenos Aires, Argentina (Dec 2006); Transient receptor potential vanilloid 1 activation in corneal epithelial cells mediates a pro-inflammatory response.
- University of Miami (June 2005); EGF mediated signaling in corneal epithelial cells.
- New York Medical College (March 2005); TRP expression is required for the mitogenic response to EGF.
- Kyoto University (December 2004); Dependence of corneal epithelial proliferation on PKC isoform expression.
- Indiana University (March 2004); How does EGF mediate control of corneal epithelial cell migration?
SELECTED PEER-REVIEWED PUBLICATIONS
- Book Chapters and Review
Reinach, PS, Zhang, F. and Capo-Aponte, JE (2010) Encyclopedia of the Eye, Corneal epithelial ionic transport mechanisms, in press, Elsevier Press New York
Reinach, PS, Pokorny, KS The corneal epithelium: Clincial relevance of cytokine-mediated responses to maintenance of corneal health. Arq. Bras Oftalmol. 71: (6 Suppl):80-6. Review
Reinach, P.S., Capó-Aponte, J.E., Mergler, S., Pokorny, K.S. Roles of corneal epithelial transport mechanisms in mediating responses to cytokines and osmotic stress, in Ocular Transporters: In Ophthalmic Diseases and Drug Delivery, pp 17-47,eds. Tombran-Tink, J. and Barnstable, C.J., Humana Press, Totowa, NJ,
SELECTED PEER-REVIEWED PUBLICATIONS
- Papers in the last three years:
Okada Y, Saika S, Shirai K, Yamanaka O, Kitano A, Wang Z, Yang H, Reinach P. JNK MAPK signaling contributes in vivo to injury-induced corneal epithelial migration. Ophthalmic Res. 2009;42(4):185-92.
Wang Z, Yang H, Zhang F, Pan Z, Capó-Aponte J, Reinach PS. (2009)Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation. Invest Ophthalmol Vis Sci. 50(10):4828-35.
Akinci MA, Turner H, Taveras M, Barash A, Wang Z, Reinach P, Wolosin JM. (2009)Molecular profiling of conjunctival epithelial side-population stem cells: atypical cell surface markers and sources of a slow-cycling phenotype. Invest Ophthalmol Vis Sci. 50(9):4162-72.
Okada Y, Senba E, Shirai K, Ueyama T, Reinach P, Saika S. (2008) Perturbed intraepithelial differentiation of corneal epithelium in c-Fos-null mice.Jpn J Ophthalmol. 2008 Jan-Feb;52(1):1-7.
Pan Z, Yang H, Mergler S, Liu H, Tachado SD, Zhang F, Kao WW, Koziel H, Pleyer U, Reinach PS (2008) Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells. Cell Calcium. 44(4):374-85.
Kitano A, Saika S, Yamanaka O, Ikeda K, Okada Y, Shirai K, Reinach PS.(2007) Emodin suppression of ocular surface inflammatory reaction Invest. Ophthalmol Vis Sci 48 (11) 5013-22.
Capó-Aponte JE, Wang Z, Akinci MA, Wolosin JM, Pokorny KS, Iserovish P, Reinach PS (2007) Potassium-chloride cotransporter mediates cell cycle progression and proliferation of human corneal cells. Cell Cycle 6(21):2709-18
Zhang, F., Yang, H., Wang, Z., Mergler, S., Liu, H., Kawakita, T., Tachado, SD., Pan, Z., Capo-Aponte, JE, Pleyer, U., Koziel, H., Kao, WW, Reinach, PS (2007) Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling. J. Cell Physiology 213 (3): 730-9.
Pan, Z. Capo-Aponte, JE, Zhang, F., Wang, Z., Pokorny, KS, Reinach, PS (2007) Differential dependence of regulatory volume decrease behavior in rabbit corneal epithelial cells on MAPK superfamily activation. Exp. Eye Res. 84: 978-90.
Capó-Aponte, J.E., Wang, Z., Bildin, V., Iserovich, P., Pan, Z., Zhang, F., Pokorny, K.S., Reinach, P.S.(2007) Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells. Exp. Eye Res. 84:1090-1103.
Capó-Aponte, J.E., Wang, Z., Bildin, V.N., Pokorny. K.S., Reinach, P.S. (2007). Fate of hypertonicity-stressed corneal epithelial cells depends on differential MAPK activation and p38MAPK/Na-K-2Cl cotransporter1 interaction. Exp. Eye Res. 84(2):361-372.
Wang, Z., Yang, H., Tachado, S.D., Capó-Aponte, J.E., Bildin, V.N., Koziel, H., Reinach, P.S. (2006). Phosphatase-induced MAPK crosstalk mediates control of corneal epithelial cell migration. Invest. Ophthal. Vis. Sci. 47(12):5267-5275.
Du, J., Zhang, F. Capó-Aponte, J.E., Tachado, S.D., Zhang, J., Yu, F.S., Koziel, H., Sack, R., Reinach, P.S. (2006). AsialoGM1 mediated IL-8 release by human corneal epithelial cells requires coexpression of TLR5. Invest. Ophthal. Vis. Sci. 47(11): 4810-4818,
Kitano, A., Saika, S., Yamanaka, O., Ikeda, K., Reinach, P.S., Nakajima, Y., Okada, Y., Shirai, K., Ohnishi, Y. (2006). Genipin suppresses subconjuntival fibroblast migration, proliferation and myofibroblast transdifferentiation. Ophthalmic Res. 38(6): 355-60.
Kitano, A., Saika, S., Yamanaka, O., Reinach, P.S., Ikeda, K., Okada, Y., Shirai, K., Ohnishi, Y. (2006). Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line. J. Cataract Refract. Surg. 32(10): 1727-1735.
Lu, J., Lu, Z., Reinach, P.S., Zhang, J., Dai, W., Lu, L., Xu, M. (2006). TGF-beta2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Exp. Cell Res. 312(18): 3631-3640.
Zhang, F., Wen, Q., Mergler, S. Yang, H., Wang, Z. Bildin, V.N., Reinach, P.S. (2006). PKC isoforms-specific enhancement of capacitative calcium entry in human corneal epithelial cells. Invest. Ophthal. Vis. Sci. 47(9): 3989-4000.
Zhuang Z.H., Sun, L., Kong, L., Yu, MC, Reinach, P., Zang Z.W., Ge, B.X. (2006). Drosophila TAB2 is required for immune activation of JNK and NF-Kappa B. Cell Signal. 964-970.
Wang L, Reinach P, Lu L (2005). TNF-a promotes cell survival through stimulation of K+ channel and NFKB activity in corneal epithelial cells. Exper Cell Res 311:39-48.
Capo-Aponte JE Iserovich P, Reinach PS (2005). Characterization of Regulatory Volume Behavior by Fluorescence Quenching in Human Corneal Epithelial Cells. Journal Membrane Biology 207:11-22.
Yang H, Mergler S, Sun X, Wang Z, Lu L, Bonanno JA, Pleyer U, Reinach PS (2005). TRPC4 Knockdown Suppresses Epidermal Growth Factor-induced Store-operated Channel Activation and Growth in Human Corneal Epithelial Cells. J Biol Chem. Sep 16;280(37):32230-7. Epub 2005 Jul 20.
Mergler S, Pleyer U, Reinach P, Bednarz J, Dannowski H, Engelmann K,Hartmann C, Yousif T. (2005) EGF suppresses hydrogen peroxide induced Ca2+ influx by inhibiting L-type channel activity in cultured human corneal endothelial cells. Exp Eye Res. Feb;80(2):285-93.
Yuan Z, Reinach P, Yuan J. Contrast sensitivity and color vision with a yellow intraocular lens. Am J Ophthalmol. 2004 Jul;138(1):138-40.
Shao C, Sima J, Zhang SX, Jin J, Reinach P, Wang Z, Ma JX (2004). Suppression of corneal neovascularization by PEDF release from human amniotic membranes. Invest Ophthalmol Vis Sci. Jun;45(6):1758-62.
Al-Nakkash, L, Iserovich, P., Coca-Prados, M., Yang, H., Reinach, PS (2004): Functional and molecular characterization of a volume-activated chloride channel in rabbit corneal epithelial cells. J. Membr. Biol. 201: 1-9.
Representative Publications out of 101:
Iserovich P, Yiming M, Wang Z, Bildin VN, Reinach PS, Fischbarg J. Epidermal growth factor stimulates fluid transport in SV40 transformed rabbit lacrimal gland cells. Adv Exp Med Biol. 2002;506(Pt A):243-7.
Mohri M, Reinach PS, Kanayama A, Shimizu M, Moskovitz J, Hisatsune T,Miyamoto Y. Suppression of the TNFalpha-induced increase in IL-1alpha expression by hypochlorite in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3190-5.
Shioda R, Reinach PS, Hisatsune T, Miyamoto Y. Osmosensitive taurine transporter expression and activity in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2916-22.
Iservoch, P, Yiming, M, Wang, Bildin, VN, Reinach, PS, Fischgarg, J. Epidrmal gowth factor stimulates fluid transport in SV40 transformed rabbit lacrimal gland cells. Adv Exp Med Biol. 2002:506(PtA):243-7.
Kang, SS, Wang L, Kao, W.-Y, Reinach, PS, Luo, L. (2001): Control of SV40-transformed RCE cell proliferation by growth factor-induced cell cycle progression. Current Eye Res. 6:397-405.
Bildin, VN, Iserovich, Fischbarg, J, Reinach, PS. (2001): Differential expression of Na:K:2Cl co transporter, glucose transporter 1 and aquaproin 1 in freshly isolated and cultured bovine corneal tissues. Exp. Biol. Med. 226 919-26.
Miyasaka, T, Kaminogawa, S, Shimizu, M, hisatsune, T, Reinach, PS Miyamoto, Y. (2001): Characterization of human taurine transporter expressed in insect cells using a recombinant biculovirus. Protein Expr. Purif. 23:389-97.
Yang, H, Wang, Z, Miyamoto Y, Reinach, PS. (2001): Cell signaling pathways mediating epidermal growth factor stimulation of Na:K:2Cl contransport activity in rabbit corneal epithelial cells. J Membr. Biol 183(2): 93-101.
Al-Nakkash L, Reinach, PS.(2001): Activation of a CFTR-mediated chloride current in a rabbit corneal epithelial cell line. Invest Ophthalmol. Vis. Sci. 42(10):2364-70.
Lu, L, Reinach, PS, Kao, WW. (2001): Corneal epithelial wound healing. Exp Biol Med (Maywood) 226(7):653-64. Review.
Kitanishi, K, Harino, S, Suzuki, M, Okamoto, N, Reinach, PS. (2001): Liposomal prostaglandin E1 enhances optic nerve head blood flow in cats. J Ocular Pharmacol Ther. 17(2):115-22.
Kuang, K, Li, Y. Wen, Q, Wang, Z, Li, J, Yang, Y, Iserovich, P, Reinach, PS, Sparrow, J, Diecke, FP, Fischbarg, J. (2001): Corneal endothelial NKCC: molecular identification, location, and contribution to fluid transport. Am J Physiol Cell Physiol. 280(3):C491-9.
Reinach, PS, Li, T, Lu, L. (2001): Okadaic acid suppresses TPA-induced differentiation by stimulating G1/S transition in human myeloblastic leukaemia ML-1 cells. Cell Prolif. 33(4):189-202.
Bildin, VN, Yang, H. Crook, RB, Fischbarg, J. and Reinach, PS. (2000) Adaptation by corneal epithelial cells to chronic hypertonic stress depends on upregulation of Na:K: 2Cl cotransporter gene and protein expression and ion transport activity. J. Membrane Biol. 177:41-50.
Kang, SS, li, T, Xu, D, Reinach, PS, and Lu, L. (2000) Inhibitory effect of PGE2 on EGF-induced MAP Kinase activity and rabbit corneal epithelial proliferation. Invest. Ophthalmol. Vis. Sci. 41:2164 -2169.
Yang, H, Reinach, PS, Koniarek, JP, Wang, T, Iserovich, P. and Fischbarg, J. (2000) Fluid transport by cultured corneal epithelial cell layers Br. J. Ophthalmol. 84:199-204.
Hara, E, Reinach, PS, Iservoch, P and Fischbarg, J, (1999). Fluxoxetine inhibits (K(+)efflux, Na(+)-K(+)-2Cl(-) contransport, and Na(+) pump) underlying volume regulation in corneal endothelial cells J. Membrane Biol. 17(1):75-85.
Harino, S, Nishimura, K, Kitanishi, K, Suzuki, M, and Reinach, PS, (1999) Role of nitric oxide in mediating retinal blood flow regulation in cats. J. Ocular Pharmacol. 15(4):295-303.
Wu, X. Torres-Zamorano, V, Yang, H, and Reinach PS. (1998) ETA receptor mediated inhibition of intracellular pH regulation in cats bovine corneal epithelial cells. Exp. Eye Res. 66(6):699-708.
Iserovich, P, Reinach, P, Yang, H, and Fischbarg, J. (1998) A novel approach to resolve cellular volume responses to an anisotonic challenge. Adv in Exp. Med Biol. 438:687-92.
Bildin, VN, Yang, H, Fischbarg, J and Reinach, PS, (1998) Effects of chronic hypertonic stress on regulatory volume increase and Na-K-2Cl cotransporter expression in cultured corneal epithelial cells. Adv. in Exp. Biol. and Med. 436:637-642.
Wu, X, Yang, H, Fischbarg, J. and Reinach, P. (1997): Regulatory volume decrease by SV40-transformed rabbit corneal epithelial cells requires ryanodine-sensitive Ca2+-induced Ca2+release. J. Membrane Biology 15:158(2):127-136.
Tao, W, Wu, X, Liou, G, Abney, TO and Reinach, PS. (1997): Endothelin receptor-mediated Ca2+ signaling and isoform expression in bovine corneal epithelial cells Invest. Ophthalmol. Vis. Sci. 38(1):130-41.
Takashima, Y, Takagi, H, T. Takahashi, M, Reinach, PS, Mircheff, AK, Warren, DW, and Yoshimura, N. (1996): Endothelin protein expression in tear glands of the rabbit Current Eye Res. 15(7):768-73.
Nishimura, K, Riva, CE, Reinach, P, Mita, S. (1996): Effects of endothelin-1 on optic nerve head blood flow in cats. J. Ocular Pharmacol Ther. 2:75-83.
Socci, RR, Tachado, SD, Aronstam, RS, Reinach, PS. (1996): Characterization of muscarinic receptor subtypes in bovine corneal epithelial cells. J. Ocular Pharm and Therapeutics 12: 259-69.
Tao, W, Liou, GI, Wu, X, Abney, TO, Reinach, PS. (1995): ETB and epidermal growth factor receptor stimulation of wound closure in bovine corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 36:2614-2622.