Research
 research

  Robert R. Sack, Ph.D.

 


SUNY State College of Optometry
Biological Sciences
33 West 42nd Street, New York, NY 10036
Office: 212-938-5782
Fax: 212-938-5537
jsack@sunyopt.edu

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Curriculum Vitae

EDUCATION | PRESENT POSITIONS | PUBLICATIONS | RESEARCH | PRESENTATIONS

 

EDUCATION

  • Undergraduate - Hunter College, 1961-63
  • Bard College- BA Graduate - Biochemistry,1963-65.
  • New York Medical College, 1966-72
  • (Ph.D.) Thesis research Chemistry Department,
         Brookhaven National Laboratory, L.I., NY

PRESENT POSITIONS:

  • Professor, Department of Biological Sciences, SUNY College of Optometry, tenured.

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PUBLICATIONS

Selected Research Publications Prior to 2004:

  1. Specificity and Biological Activity of Protein Deposited on Hydrogel Lenses. Robert A. Sack, Barrie Jones and Hattie Harvey: Invest. Ophthamol. Vis. Sci. 28, 842 (1987).
  2. Immunoglobulin Deposition on Contact Lenses Relationship to Adverse Reactions, Hydrogel Structure and Mode of Use and Giant Papillary Conjunctivitis. Barrie Jones and Robert A. Sack: CLAO 15, 4 (1989).
  3. Diurnal Tear Cycle: Evidence for a Nocturnal Inflammatory Constitutive Tear Fluid. Robert A. Sack, Kah Ooi Tan and Ami Tan: Invest Ophthalmol. Vis. Sci. 33, 626 (1992).
  4. Temporal sequence of changes in tear film composition during sleep. Kah Ooi Tan, Robert A. Sack, Brien A. Holden and Helen A. Swarbrick: Current Eye Res. 12, 1001 (1993).
  5. The effect of eye closure on protein and complement deposition on Group IV hydrogel contact lenses: relationship to tear flow dynamics. Robert A. Sack, Sonal Sathe, Leslie A. Hackworth, Mark D. P. Willcox, Brien A. Holden and Carol A. Morris: Curr. Eye Res. 15, 1092 (1996).
  6. Complement and Complement Regulatory Proteins in Human Tears. Mark D. P. Willcox, C.A. Morris, A. Thakur, R. A. Sack, J.Wickson, and W. Boey: Invest Ophthalmol Vis Sci. 38, 1 (1997).
  7. Elastase in a Major source of Caseinolytic activity in Closed Eye Tears and in Schirmer Strip Collected Samples. Miki Sakata, Robert A. Sack, Sonal Sathe, and Ann R. Beaton: Curr. Eye Res. 16, 810 (1997).
  8. Sack RA, Sathe S, Beaton A. Tear turnover and immune and inflammatory processes in the open-eye and closed-eye environments: relationship to extended wear contact lens use. Eye Contact Lens. 2003 Jan;29(1 Suppl):S80-2; discussion S83-4, S192-4.
  9. Sack RA, Sathe S, Beaton AR, Bogart B, Lew G. Changes in the diurnal pattern of the distribution of gelatinases and associated proteins in normal and pathological tear fluids: evidence that the PMN cell is a major source of MMP activity in tear fluid. Adv Exp Med Biol. 2002;506(Pt A):539-45.
  10. Sathe S, Sakata M, Beaton AR, Sack RA. Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid. Curr Eye Res. 1998;17:348-62.
  11. Sack RA, Beaton AR, Sathe S. Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. Curr Eye Res. 1999;18:186-93.
  12. Towards a closed eye model of the pre-ocular tear layer. R. Sack, A. Beaton, S. Sathe, C. Morris, M. Willcox, and B. Bogart. Prog Retin Eye Res. 19: 649-68. Review (2000).

Peer reviewed publications 2004 to present:

  1. Sack R, Beaton A, Sathe S, McNamara, N, Leonardi,A. Antibody Array Characterization of Inflammatory Mediators in Allergic and Normal Tears in the Open and Closed Eye Environments. Exp. Eye Res. (accepted in press)
  2. Lane JD, Krumholz DM, Sack RA, Morris C. Tear glucose dynamics in diabetes mellitus. Curr Eye Res. 2006;31:895-901.
  3. Du JW, Zhang F, Capo-Aponte JE, Tachado SD, Zhang J, Yu FS, Sack RA, Koziel H, Reinach PS. AsialoGM1-mediated IL-8 release by human corneal epithelial cells requires coexpression of TLR5. Invest Ophthalmol Vis Sci. 2006;47:4810-8.
  4. McNamara NA, Andika R, Kwong M, Sack RA, Fleiszig SM. Interaction of Pseudomonas aeruginosa with human tear fluid components. Curr Eye Res. 2005;30:517-25.
  5. Sack RA, Conradi L, Krumholz D, Beaton A, Sathe S, Morris C.Membrane array characterization of 80 chemokines, cytokines, and growth factors in open- and closed-eye tears: angiogenin and other defense system constituents. Invest Ophthalmol Vis Sci. 2005;46:1228-38.6.
  6. Ni M, Evans DJ, Hawgood S, Anders EM, Sack RA, Fleiszig SM.Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa. Infect Immun. 2005 ;73:2147-56.
  7. Hume E, Sack R, Stapleton F, Willcox M. Induction of cytokines from polymorphonuclear leukocytes and epithelial cells by ocular isolates of Serratia marcescens. Ocul Immunol Inflamm. 2004; 12:287-95.
  8. Fung KY, Morris C, Sathe S, Sack R, Duncan MW. Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid. Proteomics. 2004 ;4:3953-9.
  9. Sack RA, Sathe S, Beaton A, Kozinski M, Bogart B, Lew G, Sharma S, Upponi A. Is the cystatin-like domain of TSL functionally active in external ocular infections and during the normal diurnal cycle? Exp Eye Res. 2004;78:371-8.

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MAJOR AREAS OF ACTIVE RESEARCH

Proteomics of the tear film-
Evaluation of the use the tear film as a site for non-invasively continuous monitoring of glucose levels (using a glucose sensing contact lens or ocular inserts) in diabetics. Proteomics of diabetic retinopathy and macular degeneration-array analysis of vitreous fluid.

SELECTED INVITED RESEARCH PRESENTATIONS

Past co-chair of several symposiums sessions International Society for Contact Lens Research (resigned ~8 years ago from the society for personal reasons), Co-chair of several sessions at TFOS symposiums.

Invited speaker- various ICER symposiums, ARVO special interest symposium, Berlin Corneal

Immunology workshop, Ettal Ocular Immunology workshop, EVER symposium on ocular surfaces analysis, various symposiums on use of contact lenses on and extended wear basis.

Invited lecturer or symposium session chair at meetings in Canada, Holland, France, Italy, Germany, Switzerland, Spain, Czech Republic, Israel, England, Bermuda, Argentina, India, Thailand, Australia and USA. Invited research lecturer at Optometry schools at UC Berkeley, U Ohio, NECO, Department of Ophthalmology at Columbia University, University of Pennsylvania, Schepens Eye Research Institute, Harvard Medical School, Broadhurst Distinguished Lecture, Brookhaven National Laboratory, NY Ophthalmology Residents Consortium, CRCERT University New South Wales, LV Prasad Eye Institute, Hyderabad, and Centre for Molecular Biology Research, Hyderabad, India. Bausch and Lomb, Vistakon, CIBA Vision, Alcon and elsewhere.

Consultant- Bausch and Lomb, Ciba Vision Inc, Vistakon, Oculir and other companies

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