Miduturu Srinivas

Education

• PhD, , University of Florida College of Medicine,
• PhD, Doctor of Optometry, University of Florida College of Medicine,

Courses Taught Most Recent Academic Year

BVS 205FA
Pharmacology I

Publications

• Myopia Alters the Structural Organization of the Retinal Vasculature, GFAP-Positive Glia, and Ganglion Cell Layer Thickness, International Journal of Molecular Sciences 23 (11): 6202 6202, 2022
• Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy., Proceedings of the National Academy of Sciences of the United States of America 115 (26): E5934-E5943 E5934-E5943, 2018
• Human diseases associated with connexin mutations., Biochimica et biophysica acta 1860 (1): 192-201 192-201, 2018
• Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens., Investigative ophthalmology & visual science 57 (13): 5714-5722 5714-5722, 2016
• Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels., The Journal of general physiology 148 (1): 25-42 25-42, 2016
• Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine., The Journal of investigative dermatology 135 (4): 1033-1042 1033-1042, 2015
• Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus., The Journal of biological chemistry 289 (47): 32694-702 32694-702, 2014
• Altered inhibition of Cx26 hemichannels by pH and Zn2+ in the A40V mutation associated with keratitis-ichthyosis-deafness syndrome., The Journal of biological chemistry 289 (31): 21519-32 21519-32, 2014
• Functional effects of Cx50 mutations associated with congenital cataracts., American journal of physiology. Cell physiology 306 (3): C212-20 C212-20, 2014
• Connexin channel modulators and their mechanisms of action., Neuropharmacology 75 517-24 517-24, 2013
• The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions., The Journal of general physiology 142 (1): 3-22 3-22, 2013
• The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates., The Journal of membrane biology 245 (8): 453-63 453-63, 2012
• Triarylmethanes, a new class of cx50 inhibitors., Frontiers in pharmacology 3 106 106, 2012
• Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death., Circulation 125 (3): 474-81 474-81, 2012
• Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium., The Journal of general physiology 139 (1): 69-82 69-82, 2012
• Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome., The Journal of general physiology 136 (1): 47-62 47-62, 2010
• Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis., Molecular biology of the cell 20 (10): 2582-92 2582-92, 2009
• Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain., The Journal of biological chemistry 284 (7): 4484-93 4484-93, 2009
• Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating., The Journal of general physiology 132 (3): 315-27 315-27, 2008
• Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling., Investigative ophthalmology & visual science 48 (12): 5630-7 5630-7, 2007
• Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)., The Journal of pharmacology and experimental therapeutics 319 (3): 1452-8 1452-8, 2006
• Functional characterization of a naturally occurring Cx50 truncation., Investigative ophthalmology & visual science 47 (10): 4474-81 4474-81, 2006
• Mefloquine effects on the lens suggest cooperative gating of gap junction channels., The Journal of membrane biology 211 (3): 163-71 163-71, 2006
• Regulation of connexin hemichannels by monovalent cations., The Journal of general physiology 127 (1): 67-75 67-75, 2006
• Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions., Nature protocols 1 (4): 1799-809 1799-809, 2006
• New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43., FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19 (12): 1674-6 1674-6, 2005
• Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels., Biophysical journal 88 (3): 1725-39 1725-39, 2005
• Potent block of Cx36 and Cx50 gap junction channels by mefloquine., Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12364-9 12364-9, 2004
• Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina., The Journal of biological chemistry 279 (4): 2913-21 2913-21, 2004
• Closure of gap junction channels by arylaminobenzoates., Molecular pharmacology 63 (6): 1389-97 1389-97, 2003
• Prospects for rational development of pharmacological gap junction channel blockers., Current drug targets 3 (6): 455-64 455-64, 2002
• Virtual cloning, functional expression, and gating analysis of human connexin31.9., American journal of physiology. Cell physiology 283 (3): C960-70 C960-70, 2002
• Evidence for a role of the N-terminal domain in subcellular localization of the neuronal connexin36 (Cx36)., Journal of neuroscience research 69 (4): 448-65 448-65, 2002
• Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line., In vitro cellular & developmental biology. Animal 37 (9): 589-98 589-98, 2001
• Quinine blocks specific gap junction channel subtypes., Proceedings of the National Academy of Sciences of the United States of America 98 (19): 10942-7 10942-7, 2001
• Calmodulin kinase pathway mediates the K+-induced increase in Gap junctional communication between mouse spinal cord astrocytes., The Journal of neuroscience : the official journal of the Society for Neuroscience 21 (17): 6635-43 6635-43, 2001
• How to close a gap junction channel. Efficacies and potencies of uncoupling agents., Methods in molecular biology (Clifton, N.J.) 154 447-76 447-76, 2001
• Identification and functional expression of HCx31.9, a novel gap junction gene., Cell communication & adhesion 8 (4-6): 173-8 173-8, 2001
• Molecular and functional diversity of neural connexins in the retina., The Journal of neuroscience : the official journal of the Society for Neuroscience 20 (22): 8331-43 8331-43, 2000
• Properties of gap junction channels formed by Cx46 alone and in combination with Cx50., Biophysical journal 79 (4): 1954-66 1954-66, 2000
• Voltage gating properties of channels formed by a skate retinal connexin., The Biological bulletin 199 (2): 165-8 165-8, 2000
• Temporal expression of neuronal connexins during hippocampal ontogeny., Brain research. Brain research reviews 32 (1): 57-71 57-71, 2000
• TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells., Cell structure and function 24 (6): 435-41 435-41, 1999
• Functional properties of channels formed by the neuronal gap junction protein connexin36., The Journal of neuroscience : the official journal of the Society for Neuroscience 19 (22): 9848-55 9848-55, 1999
• Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells., The Journal of physiology 517 ( Pt 3) 673-89 673-89, 1999